OVID-19 has a serious impact on people's mental health. People are more likely to fear illness or death, feel helpless, and be stereotyped by others. The pandemic has had such a devastating impact on people's mental health that it can even lead to a psychological crisis. Infected patients are treated in isolation hospitals designated for COVID-19, loneliness and social isolation can trigger stress. This study aimed to determine the stress level of COVID-19 patients at the Gondang Health Center, Mojokerto Regency. The design of this research was descriptive. The population in this study was all COVID-19 patients in the isolation room of the Gondang Health Center on August 10, 2021, as many as 34 respondents. The sampling technique of this research was total sampling. The sample in this study as many as 34 people. The research instrument used the Kessler Psychological Distress Scale (K10) questionnaire. Data analysis used frequency distribution and percentage. The results suggested that almost all respondents experienced mild stress, as many as 28 respondents (82.4%), no stress as many as 3 people (8.8%), and moderate stress as many as 3 people (8.8%). This shows that the stress level of COVID-19 patients at the Gondang Health Center, Mojokerto Regency on August 10, 2021 was a mild level. This is because the isolation at the Gondang Health Center also has a psychological therapy program to prevent mental health disorders of the isolated patients, the patient's logistical needs are well met, eat nutritious food, vitamins, are given entertainment so as not to be depressed during isolation by holding gymnastics every morning. , sunbathing and fun activities are held such as singing, dancing so that patients feel happy which can increase the patient's immunity although sometimes they also feel symptoms of stress.