The high incidence of work stress in nurses is also seen in Indonesia, work stress is closely related to the ability to achieve and achieve maximum results at work, while a person's ability to solve problems has different coping strategies to reduce stress levels or pressure at work, this ability trigger a good state in the mind so as to make a person more able to control and be able to think positively. This study aims to determine the relationship between work stress and coping strategies for nurses in providing nursing services in the Covid-19 isolation room at Jatirejo Health Center Mojokerto. In this study, the design used was Correlation Analytical design with a Cross Sectional approach, the population of all room nurses in the Covid-19 Isolation Room, as many as 15 respondents were taken by total sampling technique, the sample in this study were nurses in the Covid-19 isolation room. The independent variable is Coping Strategy, the Dependent variable is Job Stress. The data was taken using the Job Stress Questionnaire and Coping Strategies and then processed by editing, coding, scoring, tabulating. Analysis of data using Crosstab or cross-test with the help of SPSS results of the analysis that the level of work stress of nurses is mostly in the moderate category (66.7%), while the coping strategies used are almost the same between those who use Problem Focused Coping coping strategies as much as (53, 3%) and those using the Emotional Focused Coping coping strategy (46.7%). In the subject of low work stress, it was found using a problem focused coping coping strategy and there was also a high work stress condition using an emotional focused coping strategy. This shows that there is a relationship between the two variables.